I'm genuinely curious, have you tried one of the asset-pipeline apps for django? I found django-pipeline actually not that bad, even though I have been recently leaning towards using front-end tools (gulp/browserify) anyway.
I have not. For the front-end I'm using Ember, and Ember-CLI takes care of Emblem templates, Sass, and CoffeeScript, plus breaking code up into ES6 modules. Eventually they plan to require using it in order to get all of the features of Ember.
I was using Jammit (ruby) for assets but recently switch the django-pipeline and it is working well. For front end apps, I use Grunt.js because I am to lazy to upgrade to something new
