"DNA vaccines expressing the envelope glycoprotein (GP) or nucleocapsid protein (NP) genes of Ebola virus were evaluated in adult, immunocompetent mice. The vaccines were delivered into the skin by particle bombardment of DNA-coated gold beads with the Powderject-XR gene gun. Both vaccines elicited antibody responses as measured by ELISA and elicited cytotoxic T cell responses as measured by chromium release assays. From one to four vaccinations with 0.5 microgram of the GP DNA vaccine resulted in a dose-dependent protection from Ebola virus challenge. Maximal protection (78% survival) was achieved after four vaccinations. "
There are a few vaccines that work in animals, they just haven't been funded to go through the trials needed to be widely used in humans. There is a good interview on Montana public radio with one of the leading researchers that touches on this:
(Rocky Mountain Lab in Montana is where a large portion of the ebola research in the nation if not world the world happens and mtpr had gotten some really good interviews as a result.)
524..2671 /gene="NP" /note="Ebola nucleoprotein; Region: Ebola_NP; pfam05505" /db_xref="CDD:147601"
"http://www.ncbi.nlm.nih.gov/pubmed/9657001?dopt=Abstract"
"DNA vaccines expressing the envelope glycoprotein (GP) or nucleocapsid protein (NP) genes of Ebola virus were evaluated in adult, immunocompetent mice. The vaccines were delivered into the skin by particle bombardment of DNA-coated gold beads with the Powderject-XR gene gun. Both vaccines elicited antibody responses as measured by ELISA and elicited cytotoxic T cell responses as measured by chromium release assays. From one to four vaccinations with 0.5 microgram of the GP DNA vaccine resulted in a dose-dependent protection from Ebola virus challenge. Maximal protection (78% survival) was achieved after four vaccinations. "
The article is from 1998. Interesting why there is still no vaccine. And this is on the virus structure - GP envelope - with attached antibody from human survivor http://www-als.lbl.gov/index.php/contact/163-structure-of-th...