No mention yet of Nick Lane and his (wonderful) books:
- Oxygen
- Power, Sex, Suicide
If you want a fascinating, very readable, well laid out argument against the entire notion of antioxidant supplementation (as well as a fascinating, technical but not too technical, pop-sci read) these are it.
tl;dr: Ingested antioxidants have no way to target the specific area in mitochondria where the damage would take place, and even if they did, it would probably be negative because free radicals are an essential cell signaling mechanism that aids in weeding out damaged cells.
- Oxygen - Power, Sex, Suicide
If you want a fascinating, very readable, well laid out argument against the entire notion of antioxidant supplementation (as well as a fascinating, technical but not too technical, pop-sci read) these are it.
tl;dr: Ingested antioxidants have no way to target the specific area in mitochondria where the damage would take place, and even if they did, it would probably be negative because free radicals are an essential cell signaling mechanism that aids in weeding out damaged cells.