States rights has been too closely associated in the popular mind with slavery and racism (via arguments over what the civil war was really about). It'll be tough to disassociate those enough to make a persuasive argument for secession.
At the point you actually want a secession movement people aren't worried about the optics of it. It's not happening because the actual cost of secession, civil war and everything else is staggering. These are one way, permanent changes where a large number of the agitators will not live to see the better world.
It's compromise, carnage and collateral damage. Doing anything else is a better option 100% of the time.
Nobody's going to hear "we're seceding because we're sick of dying from lack of healthcare" and think "ooh, I wonder if it's secretly about slavery?"
