Back in the day I made a Perl script that would use an inline encryption algorithm to decode a payload and execute it in memory so it would never hit the disk. Data after the __DATA__ line.
While applying for new job once I made a self-unpacking CV in ruby using this trick; whole binary content was compressed with zlib, I also added some blank padding to get some 'nice' numbers, so I could stuff like DATA.seek(1337 * 32, IO::SEEK_CUR); needless to say either nobody appreciated the idea, then again, what I was expecting? :D