That has little to do with supporting specific languages and environments though, and more to do with those languages not have a good method to do CA installation. I have no idea about Node.js, but Python will just use the regular trust store for the OS, because it's all just OpenSSL under the hood.
Your problem isn't with mkcert and mkcert isn't missing support for anything, but with there not being a good, universal way to manage trust stores. That's an independent issue that mkcert can't fix.
Your problem isn't with mkcert and mkcert isn't missing support for anything, but with there not being a good, universal way to manage trust stores. That's an independent issue that mkcert can't fix.