About half of my friends in grad school have had their careers damaged to varying extent by academic fraud, some have wasted lives chasing bad results (one friend lost several years chasing a bad result by Homme Hellinga), some have had bad stuff perpetrated upon them by bad actors with big names (one had her result we suspect - stolen by Carolyn Bertozzi via the review process, luckily her boss was a member of NAS and PNAS track-III'd the paper ahead of Bertozzi's publication).