We use it ourselves for our internal ecommerce backend system.
We made our own WebUSB Postage Scales and Label Printer that enables 1-click creation of consignment labels.
We pull weights from the postage scales and chuck raw ZPL over the wire to the Label Printer.
Being able to skip the bugs in operating system printing queues is amazing.
Demo:
https://vimeo.com/334547755/c387957a25