I don't think "refined" matters, except so far as once you refine sugar, you can add it to all kinds of foods, driving consumption up. That's exactly my point--eating some fruits or honey is good for your health when every calorie is valuable. Eating tons of sugar when it's cheap and added to everything is bad for your health. Just because eating some sugar was helpful in the past doesn't imply that our bodies have evolved to process arbitrarily large amounts of sugar with no ill effects whatsoever.