Honey has micronutrients HFCS doesn't have. But by far the biggest difference is price. You won't overeat honey simply because you won't want to pay 21 times more. And for a taste that is not a direct replacement of sugar and may not combine well with everything.
The amount of micronutrients in honey is inconsequential, it is measured in single digit milligrams per hundred grams. It consists primarily of sugars and water, and the main component is fructose.
