For me (Colitis), they made me worse. I had tried many brands, then settled on GB for like 3 months, I kept records, they made it worse. Within two weeks of stopping my symptoms improved.
It sounds a little bit disgusting, but have you heard of fecal transplants? I've read that this can help people with clostridium difficle infections if antibiotics don't help (which is kind of 'funny', because patients seem to get clostridum infections after antibiotics therapy...) and research is going on if this can also be used for treatment of colitis and morbus crohn (but I don't know more than that, maybe you can find already published study results about that).