But following on your own theory, if it is trivial to clone the concept on to something related then you'd have to do both anyway. After all, changing the concept and marketing it for two or more different diseases is exactly what you are advocating, and doing it only for a single disease would be the opposite!
Yeah, but I'm not going to waste my time on an area with no market, even if it just a little time. I start off with the high market thing, if it works I can modify to enter the smaller markets, but I test on the most likely first.