B52s can be completely disassembled in a shirt sleeves environment and we've barely explored on orbit construction. The ISS can't be stripped down so far which is actually causing an issue with bacterial growth in places that can be reached on orbit to be cleaned. At a certain point things that are hard/impossible to reach will reach the end of their lifespan and the inhabitants are in too much danger.

https://www.rt.com/news/iss-bacteria-mir-mutation-765/