Depends on how deep you want to go. The pioneering work in this field is the "The multiscale coarse-graining method." series of papers kicked off by Noid. Who is still a person to pay attention to in this field.
I also believe the work of Frank Noe is someone to watch for in the ML potential space for proteins.
Writer of the article here: randomization fixes most of this, but the other commenters are correct in that doesnt fully account for the clinic performance (e.g. nurse performance, which does dip during the night according to the literature). I previously thought it wasn't a major issue for clinical trials, since a separate team independent from the main ward are giving the drugs, but there isn't super strong evidence to support that. I will update the article to admit this!
This said, I am inclined to believe that this isn't a major concern for chronotherapy studies, since I haven't yet seen it being raised in any paper yet as a concern and the results seem far too strong to blame entirely on 'night nurses make more mistakes'. Fully possible that that is the case! I just am on the other side of it
Rediscovering an old love for writing that I thought had left me after highschool, now applied in the field I work in! Recommend starting your own blog if you're on the fence + being consistent about posting, it's extremely worth it
this is super interesting, had no idea this was happening! i assumed things were tending towards cheaper given sequencing prices were dropping, why are things rising elsewhere?
For synthesis, it’s mainly because there is a monopoly and the challenge (DNA assembly) is super boring in comparison to sexy things like DNA synthesis.
For robotics, it’s because Opentrons started scaling and needed to make more $$$ rather than staying small (fair to them, SoftBank dollars are attractive)
Generally speaking, biology is hard and uncertain, so the market isn’t as competitive as you’d imagine. Synthesis prices stagnated a little bit for a while in comparison to where they could be because Illumina didn’t have competition
I've also written a potentially helpful coverage piece on extracting conformations from cryo-EM data: https://www.owlposting.com/p/a-primer-on-ml-in-cryo-electron...